反应详情

Alcohol 93 (210 mg, 0.485 mmol) was stirred with 1.5% aqueous HCl/THF (3:2) (10 ml) at r.t. for 16 h. The mixture was extracted with CH2Cl2 (5×15 ml) and the combined organic phases were dried (MgSO4), filtered, and concentrated to give the triol 94 and silanol by-product as a clear, colourless oil. This material was taken forward for the subsequent transformation without purification.

1. extractionThe mixture was extracted with CH2Cl2 (5×15 ml)
2. dry with materialthe combined organic phases were dried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated