化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-Fluoro-4-(trifluoromethyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 2-Fluoro-4-(trifluoromethyl)benzoic acid | HCID 518003 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Fluoro-4-(trifluoromethyl)benzamide | HCID 605689 | — |
反応手順
The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 2-fluoro-4-(trifluoromethyl)benzoic acid (1.5 g), THF (25 mL), oxalyl chloride (0.5 mL) and ammonia gas to afford 1.35 g of the product. 1H NMR (300 MHz, DMSO d6): δ 7.65 (d, J=8.4 Hz, 1H), 7.77-7.84 (m, 3H), 7.96 (br s, 1H); MS (m/z): 208.06 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09439890B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-6e6535850c42440089aa705dbdf68ac2 |
| 出典メモ | uspto-grants-2016_09 |