HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-[(Propylamino)methyl]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 2-hydroxybenzyl(propyl)carbamate | HCID 66959640 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[(Propylamino)methyl]phenol | HCID 12995219 | 108.6% |
Reaction Steps
A solution of tert-butyl 2-hydroxybenzyl(propyl)carbamate (89 g, 0.34 mol) in MeOH (400 mL) was bubbled with HCl gas. After stirring for 5 h at room temperature, the reaction mixture was concentrated under reduced pressure to afford 61 g (90%) of 2-((propylamino)methyl)phenol as HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242964B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-2891cf56493f43e595752efec4419334 |
| Source note | uspto-grants-2016_01 |