HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-iodopyridine → 3-Amino-1-(5-chloropyridin-2-yl)-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-iodopyridine | HCID 11118148 | — |
| Reactant | benzyl 2-oxo-5-phenyl-1-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate | HCID 90082795 | — |
| Product | 3-Amino-1-(5-chloropyridin-2-yl)-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one | HCID 90080294 | — |
Reaction Steps
Intermediate 2A was prepared as described in Intermediate 1A using 5-chloro-2-iodopyridine. The racemate was purified by preparative SFC chromatography (Berger SFC MGII, CHIRALCEL® OJ-H 250×30 mm ID, 5 μm, 80/20 CO2/MeOH, 85 mL/min) to give Intermediate 3A. RT=3.44 min (H2O/CH3OH with TFA, CHROMOLITH® ODS S5 4.6×50 mm, gradient=3 min, wavelength=220 and 254 nm); MS(ES):m/z=497 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242940B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e4aa5ba10b9a4521924b4e125ed1cef8 |
| Source note | uspto-grants-2016_01 |