2-Iodopyridine → HCID 90087878, compound

Participants

Reaction Steps

Intermediate 3E was prepared from Intermediate 3D and 2-iodopyridine according to the procedure described for Example 1. The racemate was purified by preparative SFC chromatography (Berger SFC MGII, OD-H 250×30 mm ID, 5 μm, 73/17 CO2/MeOH, 85 mL/min) to give Intermediate 4E. RT=1.668 min (H2O/CH3OH with TFA, CHROMOLITH® ODS S5 4.6×50 mm, gradient=3 min, wavelength=220 and 254 nm); MS(ES):m/z=373.2 [M+H+].

Provenance & Evidence