反应详情

5-Chloro-3-methyl-2-pyridin-3-yl-1H-indole hydrochloride is synthesized based on the method described in U.S. Pat. No. 3,468,894. (4-Chloro-phenyl)-hydrazine hydrochloride (3.0 g, 16.8 mmol) and 3-propionylpyridine (2.4 g, 17.6 mmol) in ethanol (45 mL) is heated to reflux for 6 h. The mixture is then cooled to room temperature and added to HCl (4M in 1,4-dioxane, 17.6 mL). The resulting mixture is heated to reflux for 24 h. The mixture is then cooled to room temperature and the yellow precipitate is filtered and washed with methanol (10 mL) three times to give 5-chloro-3-methyl-2-pyridin-3-yl-1H-indole hydrochloride as a yellow solid. MS (ESI) m/z 243.0 and 244.9 (M+H)+.

1. custom5-Chloro-3-methyl-2-pyridin-3-yl-1H-indole hydrochloride is synthesized
2. temperatureto reflux for 6 h
3. temperatureThe resulting mixture is heated
4. temperatureto reflux for 24 h
5. temperatureThe mixture is then cooled to room temperature
6. filtrationthe yellow precipitate is filtered
7. washwashed with methanol (10 mL) three times