3-Bromo-5-fluoropyridine → 5-fluoro-2-(5-fluoro-pyridin-3-yl)-1H-indole

HRID 593577Notes

Reaction equation

HRID 593577 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6](Br)[CH:7]=1.C([N:16]1[C:24]2[C:19](=[CH:20][C:21]([F:25])=[CH:22][CH:23]=2)[CH:18]=[C:17]1B(O)O)(OC(C)(C)C)=O>>[F:25][C:21]1[CH:20]=[C:19]2[C:24](=[CH:23][CH:22]=1)[NH:16][C:17]([C:6]1[CH:5]=[N:4][CH:3]=[C:2]([F:1])[CH:7]=1)=[CH:18]2

Participants

3

Reactant 2

HCID 8202063-Bromo-5-fluoropyridineHCID 27632925-Fluoro-1H-indole-2-boronic acid, N-BOC protected

Product 1

HCID 582156405-fluoro-2-(5-fluoro-pyridin-3-yl)-1H-indole

Procedure

3-Fluoro-5-bromopyridine and N-Boc-5-fluoro-indole-2-boronic acid are processed according to the procedure described in Example 91 to give 5-fluoro-2-(5-fluoro-pyridin-3-yl)-1H-indole. (ESI) m/z 231.04 (M+H)+.

Sources & evidence

ORD record
ord-0cd5341190514b37a0e942250f2424bd
Source dataset
uspto-grants-2016_01
Patent number
US09242963B2

Reaction notes

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