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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 59363Generated: October 30, 2026

Water → HCID 136492384, compound

https://huagongshe.com/reaction/59363

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 136492395HCID 136492395—
SolventTetrahydrofuranHCID 8028—
ProductHCID 136492384HCID 13649238485.8%

Reaction Steps

The title compound was prepared according to the procedure described in Intermediate-66 by using N-(4-chloro-3-(4,5-dihydro-1-(4,4-dimethylcyclohexyl)-5-oxo-1H-1,2,4-triazol-3-yl)benzyl)-2,2,2-trifluoroacetamide (Example-117, 0.150 g, 0.348 mmol), KOH (0.039 g, 0.696 mol), water (2 mL) and THF (5.0 mL) to afford 0.100 g of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09439890B2
Source datasetuspto-grants-2016_09
ORD IDord-fde3e90688544417b0dd57ae6f444017
Source noteuspto-grants-2016_09