Potassium Hydroxide → 2-tert-Butyl-5-(5-(aminomethyl)-2-chlorophenyl)-2H-1,2,4-triazol-3(4H)-one

HRID 59364Notes

Reaction equation

HRID 59364 reaction equation
[C:1]([N:5]1[C:9](=[O:10])[NH:8][C:7]([C:11]2[CH:12]=[C:13]([CH:22]=[CH:23][C:24]=2[Cl:25])[CH2:14][NH:15]C(=O)C(F)(F)F)=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[OH-].[K+]>O>[C:1]([N:5]1[C:9](=[O:10])[NH:8][C:7]([C:11]2[CH:12]=[C:13]([CH2:14][NH2:15])[CH:22]=[CH:23][C:24]=2[Cl:25])=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 136612564N-(3-(1-tert-butyl-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-4-chlorobenzyl)-2,2,2-trifluoroacetamide

Product 1

HCID 1366125162-tert-Butyl-5-(5-(aminomethyl)-2-chlorophenyl)-2H-1,2,4-triazol-3(4H)-oneYield 100.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared according to the procedure described in Intermediate-66 by using N-(3-(1-tert-butyl-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-4-chlorobenzyl)-2,2,2-trifluoroacetamide (Example-120, 0.400 g, 1.062 mmol), KOH (0.119 g, 2.12 mmol), water (5 mL) and THE (5.0 mL) to afford 0.300 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-4e77b90a14e841e5800e5b398061de29
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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