3-Acetyl-5-bromopyridine → 1-[5-(6-chloro-1-methyl-1H-indol-2-yl)-pyridin-3-yl]-ethanone

HRID 593666Notes

Reaction equation

HRID 593666 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7](B(O)O)[N:8]2[CH3:11])=[CH:4][CH:3]=1.[C:15]([C:18]1[CH:19]=[C:20](Br)[CH:21]=[N:22][CH:23]=1)(=[O:17])[CH3:16]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:20]3[CH:19]=[C:18]([C:15](=[O:17])[CH3:16])[CH:23]=[N:22][CH:21]=3)[N:8]2[CH3:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8204233-Acetyl-5-bromopyridineHCID 441195946-Chloro-1-methyl-1H-indole-2-boronic acid

Product 1

HCID 582156811-[5-(6-chloro-1-methyl-1H-indol-2-yl)-pyridin-3-yl]-ethanone

Procedure

6-Chloro-1-methyl-indole-2-boronic acid and 5-acetyl-3-bromo-pyridine are processed according to the method described in Example 100 to give 1-[5-(6-chloro-1-methyl-1H-indol-2-yl)-pyridin-3-yl]-ethanone. MS (ESI) m/z 284.98 (M+H)+.

Sources & evidence

ORD record
ord-9fae4e8b19a94ed2bdda28a3e46cb75a
Source dataset
uspto-grants-2016_01
Patent number
US09242963B2

Reaction notes

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