HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → 6-Cyano-1-fluoro-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 2-Fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide | HCID 5140912 | — |
| Reactant | 6-Cyano-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene | HCID 18949019 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Cyano-1-fluoro-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene | HCID 18949022 | — |
Reaction Steps
6-Cyano-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene (Example 26) is converted into the carbanion by treatment with lithium diisopropylamide in THF at -78° and then reacted with N-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzothiazole-1,1-dioxide. The reaction mixture is allowed to warm to room temperature and is worked up in aqueous medium, yielding the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246952 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-8cd34d005b784e35943429391df8f304 |
| Source note | uspto-grants-1993_09 |