Potassium Phosphate, Tribasic → 4-Chloro-1-(5-(2,2-dimethyl-1,3-dioxolan-4-yl)pyridin-3-yl)-5-phenylphthalazine

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Reaction Steps

4-Chloro-1-(5-(2,2-dimethyl-1,3-dioxolan-4-yl)pyridin-3-yl)-5phenylphthalazine (1.00 g, 82.0% yield) was prepared from 1,4-dichloro-5-phenylphthalazine (0.800 g, 2.91 mmol), 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.887 g, 2.91 mmol), K3PO4 (0.617 g, 2.91 mmol), tricyclohexylphosphine (0.0160 g, 0.0580 mmol) and Pd2(dba)3 (0.0270 g, 0.0290 mmol) by the methods described for N-(tert-butyl)-5-(4-chloro-5-phenylphthalazin-1-yl)pyridine-3-sulfonamide in Example 1. The crude product was taken to next step without purification. LCMS (Condition 11): retention time 1.05 min, [M+1]=418.1.

Provenance & Evidence