HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 593760Generated: October 30, 2026
Phosphorus oxychloride → 3-(2-Chloro-4-fluorophenyl)-7-(4-chloropyrimidin-5-yl)isoxazolo[4,5-b]pyridine
https://huagongshe.com/reaction/593760
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178518073 | HCID 178518073 | — |
| Product | 3-(2-Chloro-4-fluorophenyl)-7-(4-chloropyrimidin-5-yl)isoxazolo[4,5-b]pyridine | HCID 86730417 | 100% |
Reaction Steps
A suspension of 5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol (5.0 mg, 0.015 mmol) in phosphorus oxychloride (100 μl, 1.073 mmol) was heated at 90° C. for 1 h, then allowed to cool to room temperature. The solvent was evaporated to give the title compound (5.3 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09242967B2 |
|---|
| Source dataset | uspto-grants-2016_01 |
|---|
| ORD ID | ord-1b81c02d9fda425f818b34033ac84c41 |
|---|
| Source note | uspto-grants-2016_01 |
|---|
