HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 593766Generated: October 30, 2026
Phosphorus oxychloride → 7-(4-Chloropyrimidin-5-yl)-3-(4-fluorophenyl)isoxazolo[4,5-b]pyridine
https://huagongshe.com/reaction/593766
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178518074 | HCID 178518074 | — |
| Product | 7-(4-Chloropyrimidin-5-yl)-3-(4-fluorophenyl)isoxazolo[4,5-b]pyridine | HCID 86730422 | 100.6% |
Reaction Steps
A suspension of 5-(3-(4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl) pyrimidin-4-ol (45 mg, 0.146 mmol) in phosphorus oxychloride (503 μl, 5.40 mmol) was heated at 90° C. for 1 h, then allowed to cool to room temperature. The solvent was evaporated to afford the title compound (48 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09242967B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-683e077e67304ba196cb84e05c4237bc |
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| Source note | uspto-grants-2016_01 |
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