HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylideneacetone → 3-(Aminomethyl)-6-methyl-4-phenyl-2(1H)-pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylideneacetone | HCID 637759 | — |
| Reactant | 3-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate | HCID 67124140 | — |
| Product | 3-(Aminomethyl)-6-methyl-4-phenyl-2(1H)-pyridinone | HCID 67124292 | — |
Reaction Steps
The title compound was prepared in the same manner as described for 3-(aminomethyl)-6-methyl-4-propyl-2(1H)-pyridinone (Intermediate 5) using (3E)-4-phenyl-3-buten-2-one (20 g, 137 mmol). LCMS E-S (M+H)=215.0. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.2-12.3 (br s, 1H), 7.88-8.00 (br s, 3H), 7.43-7.51 (m, 3H), 7.29-7.38 (m, 2H), 6.08 (s, 1H), 3.67-3.70 (m, 2H), 2.23 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242962B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-3f30825af9024c77a35114bf338cec0f |
| Source note | uspto-grants-2016_01 |