HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → N-(5-amino-4-chloro-2-fluorobenzyl)-2,2,2-trifluoroacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid | HCID 89736668 | — |
| Product | N-(5-amino-4-chloro-2-fluorobenzyl)-2,2,2-trifluoroacetamide | HCID 90018998 | 64,668.398% |
Reaction Steps
The title compound was prepared according to the procedure described in step-1 of Intermediate-57 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid (3.0 g), conc. H2SO4 and sodium azide (0.793 g, 0.012 mmol) to afford 2.1 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439890B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-069b0936d7534524b20bdb7e804dfc9b |
| Source note | uspto-grants-2016_09 |