HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (S)-methyl(morpholin-2-ylmethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-tert-butyl 2-(((methoxycarbonyl)amino)methyl)morpholine-4-carboxylate | HCID 90409131 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-methyl(morpholin-2-ylmethyl)carbamate | HCID 90442590 | — |
Reaction Steps
To a 4:1 solution of dichloromethane and TFA (0.1 M) was added (R)-tert-butyl 2-(((methoxycarbonyl)amino)methyl)morpholine-4-carboxylate. After 1 h the solution was then concentrated in vaccuo to give crude (S)-methyl(morpholin-2-ylmethyl)carbamate which was used in the next step without further purification. LCMS (m/z) (M+H)=175.0, Rt=0.11 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242969B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-46a673146495427b9395009439bfad5d |
| Source note | uspto-grants-2016_01 |