HCID 90408187, compound → HCID 90408404, compound

HRID 594036Notes

Reaction equation

HRID 594036 reaction equation
[OH:1][CH2:2][C:3]([NH:5][CH2:6][C@H:7]1[O:12][CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)=[O:4]>C(Cl)Cl.C(O)(C(F)(F)F)=O>[OH:1][CH2:2][C:3]([NH:5][CH2:6][C@H:7]1[O:12][CH2:11][CH2:10][NH:9][CH2:8]1)=[O:4]

Participants

3

Reactant 1

HCID 90408187HCID 90408187, compound

Product 1

HCID 90408404HCID 90408404, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

(R)-tert-butyl 2-((2-hydroxyacetamido)methyl)morpholine-4-carboxylate (1.0 equiv.) was dissolved in DCM:TFA (4:1, 0.5 M) and stirred at room temperature. After one hour the solution was concentrated to yield (S)-2-hydroxy-N-(morpholin-2-ylmethyl)acetamide. LCMS (m/z) (M+H)=175.1, Rt=0.12 min.

Workup

  1. concentrationAfter one hour the solution was concentrated

Sources & evidence

ORD record
ord-af8fe12241184cb18ff16b985594e8f1
Source dataset
uspto-grants-2016_01
Patent number
US09242969B2

Reaction notes

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