HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-((5-Bromo-3-morpholinopyridin-2-yl)oxy)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Iodoethanol | HCID 12225 | — |
| Reactant | 5-Bromo-3-morpholinopyridin-2-ol | HCID 90409853 | — |
| Product | 2-((5-Bromo-3-morpholinopyridin-2-yl)oxy)ethanol | HCID 90407952 | — |
| Product | 5-bromo-1-(2-hydroxyethyl)-3-morpholinopyridin-2(1H)-one | HCID 90408554 | — |
Reaction Steps
Method 1 was followed using 5-bromo-3-morpholinopyridin-2(1H)-one (1.0 equiv.), 2-iodoethanol (1.0 equiv.) and potassium carbonate (2.0 equiv.) at room temperature to give 5-bromo-1-(2-hydroxyethyl)-3-morpholinopyridin-2(1H)-one and 2-((5-bromo-3-morpholinopyridin-2-yl)oxy)ethanol as a mixture of two isomers (˜5:1 ratio). LCMS (m/z) (M+H)=303/305, Rt=0.47 min and 0.62 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242969B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-d1338515b33441cca9b99a0399b6a54d |
| Source note | uspto-grants-2016_01 |