HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-bromo-4-(hydroxymethyl)-N-(3-(trifluoromethyl)phenyl)benzamide → 3-bromo-4-formyl-N-(3-(trifluoromethyl)phenyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-bromo-4-(hydroxymethyl)-N-(3-(trifluoromethyl)phenyl)benzamide | HCID 90407963 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-bromo-4-formyl-N-(3-(trifluoromethyl)phenyl)benzamide | HCID 90408797 | 100% |
Reaction Steps
MnO2 (8.0 equiv.) was added into a solution of 3-bromo-4-(hydroxymethyl)-N-(3-(trifluoromethyl)phenyl)benzamide (1.0 equiv.) in DCM (0.14 M). The suspension was stirred at rt for 1 hr. The mixture was filtered over celite and concentrated to yield 3-bromo-4-formyl-N-(3-(trifluoromethyl)phenyl)benzamide in 100% yield. LC/MS (m/z)=373.9 (MH+), Rt=0.0.94 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242969B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-4e48c0fa86af45f8b79503bd0b7583b0 |
| Source note | uspto-grants-2016_01 |