Potassium Carbonate → 2,6-Dichloro-4-methoxypyridine

Temperatur

70 °C

A mixture of 2,6-dichloro-4-nitropyridine (1.0 equiv.), potassium carbonate (3 equiv.) and methanol (20 equiv.) were heated to 70° C. for 25 min in the microwave. The reaction mixture was diluted with methanol and was decanted from remaining solids. After concentration, the mixture was partitioned between water and EtOAc. The organic phase was washed with brine and dried over sodium sulfate. The solution was concentrated and dried under vacuo to give 2,6-dichloro-4-methoxypyridine in 88% yield. LCMS (m/z) (M+H)=177.9/179.9, Rt=0.72 min.

1. customwas decanted
2. concentrationAfter concentration
3. customthe mixture was partitioned between water and EtOAc
4. washThe organic phase was washed with brine
5. dry with materialdried over sodium sulfate
6. concentrationThe solution was concentrated
7. customdried under vacuo

ORD-Eintrag

ord-6c7a5f9a523a4876b4d4c9633ffa9243

Quelldatensatz

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09242969B2