反应详情

温度

70 °C

A mixture of 2,6-dichloro-4-nitropyridine (1.0 equiv.), potassium carbonate (3 equiv.) and methanol (20 equiv.) were heated to 70° C. for 25 min in the microwave. The reaction mixture was diluted with methanol and was decanted from remaining solids. After concentration, the mixture was partitioned between water and EtOAc. The organic phase was washed with brine and dried over sodium sulfate. The solution was concentrated and dried under vacuo to give 2,6-dichloro-4-methoxypyridine in 88% yield. LCMS (m/z) (M+H)=177.9/179.9, Rt=0.72 min.

1. customwas decanted
2. concentrationAfter concentration
3. customthe mixture was partitioned between water and EtOAc
4. washThe organic phase was washed with brine
5. dry with materialdried over sodium sulfate
6. concentrationThe solution was concentrated
7. customdried under vacuo