Water → HCID 60725715, compound

HRID 594095Notes

Reaction equation

HRID 594095 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1.O.ClCCl.[CH2:16]([NH2:20])[CH:17]([CH3:19])[CH3:18]>>[CH3:18][CH:17]([CH3:19])[CH2:16][NH:20][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 6558IsobutylamineHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

Product 1

HCID 60725715HCID 60725715, compound

Procedure

A mixture of 2-chloro-4-(trifluoromethyl)pyrimidine (548 mg, 3 mmol) in isobutylamine (1.5 mL) was stirred at room temperature for 17 hours. To the mixture was added water (5 mL) and dichloromethane (5 mL). The organic layer was separated and purified by flash silica (Si) chromatography (0-100% dichloromethane-cyclohexane gradient) to give the title compound (455 mg) as a colourless oil. LCMS (2 min, formic) Rt 1.20 min, m/z (ES+) 220 (M+H).

Workup

  1. customThe organic layer was separated
  2. custompurified by flash silica (Si) chromatography (0-100% dichloromethane-cyclohexane gradient)

Sources & evidence

ORD record
ord-4164db6a1d7c4b62a1c92db8ac19aa73
Source dataset
uspto-grants-2016_01
Patent number
US09242972B2

Reaction notes

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