3-(6-Methyl-5-nitro-2-pyridinyl)-1,3-oxazolidin-2-one → 3-(5-Amino-6-methyl-2-pyridinyl)-1,3-oxazolidin-2-one

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Reaction Steps

A solution of 3-(6-methyl-5-nitro-2-pyridinyl)-1,3-oxazolidin-2-one (which may be prepared, for example, according to Intermediate 3) (200 mg, 0.896 mmol) was stirred rapidly over 10% palladium on carbon (30 mg, 0.028 mmol) under an atmosphere of hydrogen at room temperature for 3 hours. The catalyst was then removed by filtration through a pad of celite. The filtrate was evaporated in vacuo to give the title compound (155 mg) as a white solid. LCMS (2 min, formic) Rt 0.38 min, m/z (ES+) 194 (M+H).

Provenance & Evidence