Cesium carbonate → 4-((3,5-dimethylisoxazol-4-yl)-methoxy)-N-(5-ethylpyrimidin-2-yl)benzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-chloro-5-ethylpyrimidine (0.021 mL, 0.177 mmol), 4-{[(3,5-dimethyl-4-isoxazolyl)methyl]oxy}benzenesulfonamide (50 mg, 0.177 mmol), palladium(II) acetate (0.397 mg, 1.770 μmol), Xantphos (2.048 mg, 3.54 μmol) and cesium carbonate (144 mg, 0.443 mmol) was prepared in 1,4-dioxane (2 mL). The reaction vessel was sealed and heated by microwaves to 130° C. for 30 minutes. After cooling the reaction, additional Xantphos (2.048 mg, 3.54 μmol) and palladium(II) acetate (0.397 mg, 1.770 μmol) were added. The reaction was heated by microwaves to 130° C. for a further 30 minutes. The reaction mixture was then diluted with methanol (2 mL) and passed through a silica solid phase extraction (SPE) cartridge to remove particulates. The filtrate was evaporated in vacuo and purified by mass directed autoprep (formic acid modifier) to give the title compound (19 mg). LCMS (2 min, formic) Rt 0.93 min, m/z (ES+) 389 (M+H)

Provenance & Evidence