反应详情

A solution of methyl 2-phenoxythiazole-4-carboxylate (265 mg; 1.12 mmol) in anh. EtOH (6 ml) was treated at rt with NaBH4 (213 mg; 5.64 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 63 h. After concentration to dryness under reduced pressure, water was added, and the resulting mixture was extracted with DCM. The organic layer was dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure. Purification by FC (DCM/MeOH=30/1) afforded (2-phenoxythiazol-4-yl)methanol as a colorless oil. LC-MS (conditions A): tR=0.58 min.; [M+H]+: 208.06 g/mol.

1. concentrationAfter concentration to dryness under reduced pressure, water
2. additionwas added
3. extractionthe resulting mixture was extracted with DCM
4. dry with materialThe organic layer was dried over anh. MgSO4
5. filtrationfiltered
6. concentrationconcentrated to dryness under reduced pressure
7. customPurification by FC (DCM/MeOH=30/1)