HCID 69082439, compound → HCID 86695612, compound

HRID 594230Notes

Reaction equation

HRID 594230 reaction equation
[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)=[CH:4][N:3]=[CH:2]1>C(Cl)Cl.O=[Mn]=O>[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 69082439HCID 69082439, compound

Product 1

HCID 86695612HCID 86695612, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of (3-(thiazol-5-yl)phenyl)methanol (162 mg; 0.84 mmol) in anh. DCM (6 ml) was treated with MnO2 (1.104 g; 12.70 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 3 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(thiazol-5-yl)benzaldehyde as an orange solid. LC-MS (conditions A): tR=0.58 min.; [M+H]+: 190.02 g/mol.

Workup

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with DCM
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-c7018134b0b64f61b0ea05b4db520123
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

Loading…