Sodium borohydride → HCID 21660613, compound

Participants

Reaction Steps

A solution of methyl 6-(thiazol-2-yl)picolinate (230 mg; 1.04 mmol) in anh. EtOH (3 ml) was treated with NaBH4 (197 mg; 5.22 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 17 h. After concentration to dryness under reduced pressure, the resulting residue was treated with water, and extracted with DCM. The organic layer was then dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure. Purification by FC (DCM/MeOH=25/1) afforded (6-(thiazol-2-yl)pyridin-2-yl)methanol as an orange solid. LC-MS (conditions A): tR=0.45 min.; [M+H]+: 193.05 g/mol.

Provenance & Evidence