HCID 69084602, compound → 3-(1H-1,2,3-triazol-1-yl)benzaldehyde

HRID 594252Notes

Reaction equation

HRID 594252 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[N:2]1>C(Cl)Cl.O=[Mn]=O>[N:1]1([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])[CH:5]=[CH:4][N:3]=[N:2]1

Participants

4

Reactant 1

HCID 69084602HCID 69084602, compound

Product 1

HCID 834815293-(1H-1,2,3-triazol-1-yl)benzaldehyde

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of (3-(1H-1,2,3-triazol-1-yl)phenyl)methanol (55 mg; 0.31 mmol) in anh. DCM (1 ml) was treated with MnO2 (411 mg; 4.73 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 2 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(1H-1,2,3-triazol-1-yl)benzaldehyde as a colorless solid. LC-MS (conditions A): tR=0.45 min.; [M+H]+: 174.09 g/mol.

Workup

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with DCM
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-30590ce99abd4e7d956920c9f258784d
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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