(5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methanol → 3-Pyridinecarboxaldehyde, 5-chloro-6-(difluoromethoxy)-

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Reaction Steps

A solution of (5-chloro-6-(difluoromethoxy)pyridin-3-yl)methanol (1.000 g; 4.77 mmol) in anh. DCM (40 ml) was treated with MnO2 (6.222 g; 71.57 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 3 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 5-chloro-6-(difluoromethoxy)nicotinaldehyde as a yellow oil. LC-MS (conditions A): tR=0.72 min.; no ionisation.

Provenance & Evidence