(2-(5-Methylthiazol-2-yl)pyridin-4-yl)methanol → 2-(5-Methylthiazol-2-yl)isonicotinaldehyde

Participants

Reaction Steps

A solution of (2-(5-methylthiazol-2-yl)pyridin-4-yl)methanol (1.910 g; 9.26 mmol) in anh. DCE (80 ml) was treated with MnO2 (4.025 g; 46.30 mmol), and the resulting mixture was heated at reflux, under nitrogen, for 1.5 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 2-(5-methylthiazol-2-yl)isonicotinaldehyde as an off-white solid. LC-MS (conditions A): tR=0.65 min.; [M+H]+: 205.35 g/mol.

Provenance & Evidence