Diethyl Ether → HCID 15058653, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of commercially available ethyl 4-hydroxybenzoate (2.500 g; 15.04 mmol), K2CO3 (4.158 g; 30.08 mmol), and 1-fluoro-2-iodoethane (2.617 g; 15.04 mmol) in anh. DMF (30 ml) was heated to 70° C., under nitrogen, for 2.5 h. After cooling to rt, Et2O (100 ml) and water (50 ml) were added. The separated organic layer was further washed with water (2×50 ml), dried over anh. MgSO4, filtered, concentrated to dryness under reduced pressure, and the residue was further dried under HV affording ethyl 4-(2-fluoroethoxy)benzoate as a colorless solid. LC-MS (conditions D): tR=0.96 min.; no ionisation.

Provenance & Evidence