反应详情

温度

0 °C

A cooled (0° C.) slightly yellow solution of methyl 5-([1,1′-biphenyl]-2-yl)-5-(1,1-dimethylethylsulfinamido)pentanoate (270 mg; 0.69 mmol) in MeOH (4 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (0.35 ml; 1.40 mmol). The resulting yellow mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 1 h. The reaction mixture was then concentrated to dryness under reduced pressure and the colorless solid residue was further dried under HV to give the chlorhydrate salt of methyl 5-([1,1′-biphenyl]-2-yl)-5-aminopentanoate as a colorless solid. LC-MS (conditions A): tR=0.57 min.; [M+H]+: 284.13 g/mol.

1. waitat rt for 1 h
2. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
3. customthe colorless solid residue was further dried under HV