HCID 69081417, compound → HCID 69083694, compound

Participants

Reaction Steps

A mixture of 6-(2-(benzyloxy)-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)-5,6-dihydropyridin-2(1H)-one (313 mg; 0.64 mmol), and 10% Pd(C) (300 mg) in anh. EtOH (20 ml) was stirred at rt, under hydrogen atmosphere (1 atm), for 17 h. Filtration over a pad of celite, concentration to dryness under reduced pressure, and additional drying under HV afforded 6-(2-hydroxy-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one as a grey solid. LC-MS (conditions E): tR=0.73 min.; [M+H]+: 396.24 g/mol.

Provenance & Evidence