Sodium Hydroxide → 5-(2,6-Dimethoxyphenyl)-5-((quinolin-3-ylmethyl)amino)pentanoic acid

関与物質

反応手順

A yellow solution of methyl 5-(2,6-dimethoxyphenyl)-5-((quinolin-3-ylmethyl)amino)-pentanoate (1.320 g; 3.23 mmol; 1.0 equiv.) in MeOH (15 ml) was treated at rt with a solution of 1 M aq. NaOH (6.5 ml; 6.5 mmol; 2.0 equiv.). The resulting solution was further stirred at rt for 1 h45. Concentration to dryness under reduced pressure, and subsequent drying under HV afforded 5-(2,6-dimethoxyphenyl)-5-((quinolin-3-ylmethyl)amino)pentanoic acid as a beige solid. LC-MS (conditions B): tR=0.59 min.; [M+H]+: 395.36 g/mol.

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