Hydrochloric Acid → HCID 69080162, compound

Participants

Reaction Steps

A solution of ethyl 2-(2-fluoro-6-methoxyphenyl)-4,5-dioxo-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-3-carboxylate (2.937 g; 6.26 mmol) in dioxane (13 ml) was treated with 25% hydrochloric acid (13 ml). The resulting mixture was then refluxed, under nitrogen, for 11 h. After cooling to rt, DCM and aq. sat. NaHCO3 were added. The separated aqueous layer was further extracted with DCM. The mixed organic layers were washed with brine, dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure affording 5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione which was used for the next step without additional purification. LC-MS (conditions A): tR=0.85 min.; [M+H]+: 397.99 g/mol.

Provenance & Evidence