HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-fluoro-3-methyl-1H-indole-2-propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate | HCID 19794669 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-fluoro-3-methyl-1H-indole-2-propanoic acid | HCID 22141166 | 102% |
Reaction Steps
A mixture of isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate (0.42 g),1N sodiumhydroxide (6.3 ml) and methanol (20 ml) are stirred at room temperature for 4 hours. The reaction mixture is poured into water, washed with methylene chloride, acidified with 1N HCl and extracted with methylene chloride. The organic layer, dried and evaporated, affords 0.36 g of 5-fluoro-3-methyl-1H-indole-2-propanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246957 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-ce2094f8a0e9499fa6e6eca4f823126b |
| Source note | uspto-grants-1993_09 |