Hydrochloric Acid → HCID 69082599, compound

Participants

Reaction Steps

A cooled (0° C.) solution of tert-butyl 3-(2,6-dimethoxyphenyl)-5-oxo-4-(4-(trifluoromethoxy)-benzyl)piperazine-1-carboxylate (540 mg; 1.05 mmol) in anh. DCM (10 ml) was treated dropwise with 4 M HCl in dioxane (4.00 ml; 16.00 mmol), and the resulting mixture was further stirred at rt, under nitrogen, for 16 h. The reaction mixture was concentrated to dryness under reduced pressure, the resulting residue was dissolved in DCM, and washed successively with 1 M aq. NaOH, aq. sat. NaHCO3, and brine. The organic layer was dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure. Purification by FC (DCM/MeOH=10/1) afforded 6-(2,6-dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)piperazin-2-one as an orange oil. LC-MS (conditions D): tR=0.85 min.; [M+H]+: 411.13 g/mol.

Provenance & Evidence