Water → 2-(2,6-Dimethoxyphenyl)-2-((4-(trifluoromethoxy)benzyl)-amino)ethanol

Participants

Reaction Steps

A cooled (0° C.) mixture of LiAlH4 (6 mg; 0.15 mmol) in anh. THF (1 ml) was treated dropwise with a solution of ethyl 2-(2,6-dimethoxyphenyl)-2-((4-(trifluoromethoxy)benzyl)amino)acetate (65 mg; 0.15 mmol) in anh. THF (1 ml). The resulting mixture was further stirred at rt, under nitrogen, for 1 h. Water (6 μl), 15% aq. NaOH (6 μl), and water (18 μl) were then successively added, and the heterogeneous mixture was filtered. The filtrate was concentrated to dryness under reduced pressure, and the oily residue was further dried under HV affording 2-(2,6-dimethoxyphenyl)-2-((4-(trifluoromethoxy)benzyl)-amino)ethanol as a yellow oil. LC-MS (conditions E): tR=0.59 min.; [M+H]+: 372.10 g/mol.

Provenance & Evidence