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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594432Generated: October 30, 2026

3-(1,3-Thiazol-2-yl)benzaldehyde → 6-(2,6-Dimethoxyphenyl)-1-(3-(thiazol-2-yl)benzyl)piperidin-2-one

https://huagongshe.com/reaction/594432

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(1,3-Thiazol-2-yl)benzaldehydeHCID 18525725—
ReactantMethyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 69082713—
Product6-(2,6-Dimethoxyphenyl)-1-(3-(thiazol-2-yl)benzyl)piperidin-2-oneHCID 69083771—

Reaction Steps

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with commercially available 3-(thiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.82 min.; [M+H]+: 409.14 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-f87069fb02a446e1a097e0d056ab7bfa
Source noteuspto-grants-2016_01