2-Bromo-4-pyridinecarboxaldehyde → HCID 86695637, compound

HRID 594454Notes

Reaction equation

HRID 594454 reaction equation
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[Br:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][N:28]=1)[CH:24]=O>>[Br:20][C:21]1[CH:22]=[C:23]([CH2:24][N:1]2[CH:2]([C:10]3[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=3[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]2=[O:8])[CH:26]=[CH:27][N:28]=1

Participants

3

Reactant 2

HCID 27629912-Bromo-4-pyridinecarboxaldehydeHCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate

Product 1

HCID 86695637HCID 86695637, compound

Procedure

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with commercially available 2-bromoisonicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.75 min.; [M+H]+: 404.91 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-06d6b47ebd2d43af82b8424397dd2fe1
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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