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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594461Generated: October 31, 2026

3-(5-Methylthiazol-2-yl)benzaldehyde → 6-(2,6-Dimethoxyphenyl)-1-(3-(5-methylthiazol-2-yl)benzyl)piperidin-2-one

https://huagongshe.com/reaction/594461

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(5-Methylthiazol-2-yl)benzaldehydeHCID 53273723—
ReactantMethyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 69082713—
Product6-(2,6-Dimethoxyphenyl)-1-(3-(5-methylthiazol-2-yl)benzyl)piperidin-2-oneHCID 69083268—

Reaction Steps

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 3-(5-methylthiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.87 min.; [M+H]+: 423.11 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-555bcce41c074217bb5425dc054ec1ba
Source noteuspto-grants-2016_01