Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate → 1-(3-(2H-1,2,3-triazol-2-yl)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

HRID 594462ノート

反応式

HRID 594462 の反応式
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[N:20]1[N:21]([C:25]2[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=2)[CH:28]=O)[N:22]=[CH:23][CH:24]=1>>[N:20]1[N:21]([C:25]2[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=2)[CH2:28][N:1]2[CH:2]([C:10]3[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=3[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]2=[O:8])[N:22]=[CH:23][CH:24]=1

参加物

3

反応物 2

HCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 834815283-(2H-1,2,3-triazol-2-yl)benzaldehyde

生成物 1

HCID 690851891-(3-(2H-1,2,3-triazol-2-yl)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

実験手順

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 3-(2H-1,2,3-triazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.83 min.; [M+H]+: 393.13 g/mol.

後処理

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

出典と根拠

ORDレコード
ord-a1ca8b4bcf5a43af816dde027b50c762
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

読み込み中…