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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594466Generated: October 31, 2026

Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate → 1-(2-Chloro-5-(pyridin-2-yl)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594466

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 69082713—
Reactant2-Chloro-5-(pyridin-2-yl)benzaldehydeHCID 86695609—
Product1-(2-Chloro-5-(pyridin-2-yl)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69083644—

Reaction Steps

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 2-chloro-5-(pyridin-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.74 min.; [M+H]+: 437.10 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-55f26bd801e94568bc429efccec01182
Source noteuspto-grants-2016_01