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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594469Generated: October 30, 2026

6-(1H-Pyrazol-1-yl)-2-pyridinecarboxaldehyde → 1-((6-(1H-pyrazol-1-yl)pyridin-2-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594469

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(1H-Pyrazol-1-yl)-2-pyridinecarboxaldehydeHCID 10511407—
ReactantMethyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 69082713—
Product1-((6-(1H-pyrazol-1-yl)pyridin-2-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69082861—

Reaction Steps

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 6-(1H-pyrazol-1-yl)picolinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 392.97 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-0fd7473c50ab49a494b936147d44290a
Source noteuspto-grants-2016_01