HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyridin-2-yl)benzaldehyde → 6-(2,4-Dimethoxypyridin-3-yl)-1-(3-(pyridin-2-yl)benzyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyridin-2-yl)benzaldehyde | HCID 3710039 | — |
| Reactant | Methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate | HCID 69082421 | — |
| Product | 6-(2,4-Dimethoxypyridin-3-yl)-1-(3-(pyridin-2-yl)benzyl)piperidin-2-one | HCID 69083432 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate with commercially available 3-(pyridin-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.52 min.; [M+H]+: 403.81 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-7e265db36be94680b7866ffde0b17b60 |
| Source note | uspto-grants-2016_01 |