HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenyl-1,3-thiazole-4-carbaldehyde → 6-(2,4-Dimethoxypyridin-3-yl)-1-((2-phenylthiazol-4-yl)methyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenyl-1,3-thiazole-4-carbaldehyde | HCID 736524 | — |
| Reactant | Methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate | HCID 69082421 | — |
| Product | 6-(2,4-Dimethoxypyridin-3-yl)-1-((2-phenylthiazol-4-yl)methyl)piperidin-2-one | HCID 69081444 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate with commercially available 2-phenylthiazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.74 min.; [M+H]+: 409.83 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-be8f1ec6ba5e4fb3b144ff7bb237201f |
| Source note | uspto-grants-2016_01 |