HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1,3-Thiazol-2-yl)benzaldehyde → 6-(3,5-Dimethoxypyridin-4-yl)-1-(3-(thiazol-2-yl)benzyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1,3-Thiazol-2-yl)benzaldehyde | HCID 18525725 | — |
| Reactant | Methyl 5-amino-5-(3,5-dimethoxypyridin-4-yl)pentanoate | HCID 69082669 | — |
| Product | 6-(3,5-Dimethoxypyridin-4-yl)-1-(3-(thiazol-2-yl)benzyl)piperidin-2-one | HCID 69083823 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(3,5-dimethoxypyridin-4-yl)pentanoate with commercially available 3-(thiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.52 min.; [M+H]+: 409.72 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-24ce47d0df96461ba739275256596f57 |
| Source note | uspto-grants-2016_01 |