Methyl 5-amino-5-(3,5-dimethoxypyridin-4-yl)pentanoate → 1-(3-(2H-1,2,3-triazol-2-yl)benzyl)-6-(3,5-dimethoxypyridin-4-yl)piperidin-2-one

HRID 594485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594485
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][N:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[N:20]1[N:21]([C:25]2[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=2)[CH:28]=O)[N:22]=[CH:23][CH:24]=1>>[N:20]1[N:21]([C:25]2[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=2)[CH2:28][N:1]2[CH:2]([C:10]3[C:15]([O:16][CH3:17])=[CH:14][N:13]=[CH:12][C:11]=3[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]2=[O:8])[N:22]=[CH:23][CH:24]=1

Komponenten

3

Edukt 2

HCID 69082669Methyl 5-amino-5-(3,5-dimethoxypyridin-4-yl)pentanoateHCID 834815283-(2H-1,2,3-triazol-2-yl)benzaldehyde

Produkt 1

HCID 690809841-(3-(2H-1,2,3-triazol-2-yl)benzyl)-6-(3,5-dimethoxypyridin-4-yl)piperidin-2-one

Versuchsvorschrift

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(3,5-dimethoxypyridin-4-yl)pentanoate with 3-(2H-1,2,3-triazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.52 min.; [M+H]+: 393.71 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-16b0263156e9427d9408a6efd7445056
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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