Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate → HCID 86695639, compound

HRID 594487Notes

Reaction equation

HRID 594487 reaction equation
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[F:20][CH:21]([F:32])[O:22][C:23]1[C:30]([CH3:31])=[CH:29][C:26]([CH:27]=O)=[CH:25][N:24]=1>>[F:32][CH:21]([F:20])[O:22][C:23]1[N:24]=[CH:25][C:26]([CH2:27][N:1]2[CH:2]([C:10]3[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=3[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]2=[O:8])=[CH:29][C:30]=1[CH3:31]

Participants

3

Reactant 2

HCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 86695640HCID 86695640, compound

Product 1

HCID 86695639HCID 86695639, compound

Procedure

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 6-(difluoromethoxy)-5-methylnicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.86 min.; [M+H]+: 406.88 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-1e6cf687492e40bba0b1ffa3bee80aba
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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