Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate → HCID 69083322, compound

HRID 594488Notes

Reaction equation

HRID 594488 reaction equation
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[CH:20]1([C:23]2[C:24]([O:31][CH:32]([F:34])[F:33])=[N:25][CH:26]=[C:27]([CH:30]=2)[CH:28]=O)[CH2:22][CH2:21]1>>[CH:20]1([C:23]2[CH:30]=[C:27]([CH2:28][N:1]3[CH:2]([C:10]4[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=4[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]3=[O:8])[CH:26]=[N:25][C:24]=2[O:31][CH:32]([F:34])[F:33])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 86695641HCID 86695641, compound

Product 1

HCID 69083322HCID 69083322, compound

Procedure

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 5-cyclopropyl-6-(difluoromethoxy)nicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.90 min.; [M+H]+: 432.88 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-aaad354ab5394d9ab4a9e77d09a2f442
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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